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Connective Tissue Disease Screen

What Is the CTD Connective Tissue Disease Screen?

The Connective Tissue Disease (CTD) Screen is a specialised blood test designed to help identify autoimmune conditions that affect connective tissues, including joints, muscles, skin and internal organs.

Autoimmune connective tissue diseases occur when the immune system mistakenly attacks healthy tissues. This screen detects specific autoantibodies associated with conditions such as lupus, Sjögren’s syndrome, scleroderma, polymyositis and mixed connective tissue disease.

It is commonly recommended for individuals experiencing symptoms such as persistent joint pain, muscle weakness, unexplained rashes, fatigue or inflammation.

What This Test Measures

Your CTD Screen includes detailed analysis of:

  • Double Stranded DNA Antibody (dsDNA Ab)

  • Anti-Nuclear Antibody (ANA)

  • Anti-Ro (SSA)

  • Anti-La (SSB)

  • Anti-Jo-1

  • Anti-Scl-70

  • Anti-CENP

  • Anti-Sm

  • Anti-U1RNP

  • Mi-2

  • Anti-Th/To

  • PM/Scl (Prn/Sci)

  • RNA Polymerase III

 

These markers help detect autoimmune activity, assess immune system abnormalities and support diagnosis of connective tissue disorders. Early detection allows for timely referral and management.